Characterization of the cellular transport mechanisms for the anti-cachexia candidate compound TCMCB07

Authors: Yongjun Hu, Kenneth A. Gruber, David E. Smith Abstract Background Cachexia is a debilitating, life-threatening condition whose pathology includes reduced food intake accompanied by hypermetabolism, leading to a catabolic state. The hypothalamic melanocortin system is a critical regulator of metabolic rate with effects being mediated through the melanocortin-4 receptor (MC4R). MC4R activation is also…

Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease–associated cachexia

Authors: Xinxia Zhu, Michael F. Callahan, Kenneth A. Gruber, Marek Szumowski, and Daniel L. Marks Abstract Cachexia, a devastating wasting syndrome characterized by severe weight loss with specific losses of muscle and adipose tissue, is driven by reduced food intake, increased energy expenditure, excess catabolism, and inflammation. Cachexia is associated with poor prognosis and high…